乳腺癌复发转移特点与分子分型相关性研究

乳腺癌复发转移特点与分子分型相关性研究 张莹徐斌刘慧1邵营波陈琦刘朝俊贺亚宁 摘要目的摘要目的：探索乳腺癌术后复发转移特点与分子分型的相关性，为复发转移性乳腺癌 患者进行个体化治疗提供理论依据及预测预后。方法方法：回顾性分析 190 例复发转移性 乳腺癌患者的临床资料并进行统计学分析，复发转移部位、数量、及分子分型改变率 的差异性比较采用2 检验， Kaplan-Meier 法用于生存率的的估计，Log-rank 检验进行 组间生存率比较。结果结果：HER-2 enrich 型及 Triple Negative 型易存在多发转移灶，但差 异无统计学意义(P=0.502)。Luminal A 型变异率最高； HER-2 enrich 型变异率最低， 差异有统计学意义(P=0.006)。HER-2 enrich 型及 Triple Negative 更易发生局部复发和区 域淋巴结转移，但差异无统计学意义(P=0.112)。Luminal 型乳腺癌易发生骨转移 (P0.001)，HER-2 enrich 型及 Triple Negative 型乳腺癌易发生内脏转移 (P=0.048)。 HER-2 enrich 型及 Triple Negative 型乳腺癌易早期出现复发转移(P0.0001)，局部复发 和区域淋巴结转移 (P0.0001)，内脏转移(P0.0001)。各分型乳腺癌出现骨转移的时间 差异无统计学意义(P=0.642)，无进展生存期各分型间也无差异 (P=0.171)。结论结论：乳腺 癌的复发转移特点与原发灶分子分型密切相关，分子分型可作为预测患者预后的依据， 对乳腺癌术后复发转移进行个体化筛查及治疗有重要意义。 关键词：分子分型；转移性乳腺癌，对比分析关键词：分子分型；转移性乳腺癌，对比分析 Characteristics and molecular typing of breast cancer recurrence and metastasis Zhang Ying XuBin LiuHui Shao Yingbo Chen Qi Liu Chaojun He Yaning The three ward of mammary gland of the Affiliated Tumor Hospital of Zhengzhou University Abstract Objective:To explore the relationship between the characteristics of recurrence and metastasis of breast cancer and the molecular typing of breast cancer, and to provide a theoretical basis for the treatment of recurrent and metastatic breast cancer and predict prognosis. s: a retrospective analysis of 190 cases of recurrence and metastasis of breast cancer patients with the clinical data and the statistical analysis, recurrence and metastasis of the tumor location, number, and molecular typing change rate differences compared with 2 test and Kaplan Meier for estimation of survival, log rank test was 作者单位：450000 郑州大学附属肿瘤医院（河南省肿瘤医院）乳腺科三病区 通信作者：刘慧 Email：liuhui691221@ used for group survival rate. Results: HER-2enrich and Triple Negative were prone to multiple metastases, but the difference was not statistically significant (P=0.502). The variation of LuminalA was the highest, and the variation of HER-2enrich was the lowest, and the difference was statistically significant (P=0.006). HER-2 enrich and Triple Negative were more prone to local recurrence and regional lymph node metastasis, but the difference was not statistically significant (P=0.112). The breast cancer of Luminal is prone to bone metastasis (P0.001), HER-2enrich and Triple Negative breast cancer prone to visceral metastasis (P=0.048). Enrich Triple and Negative HER-2 breast cancer recurrence and metastasis (P0.0001), local recurrence and regional lymph node metastasis (P0.0001), visceral metastasis (P0.0001). There was no significant difference in the time difference of bone metastasis in breast cancer (P=0.642), and there was no difference between the different types of breast cancer (P=0.171). Conclusion:The recurrence and metastasis of breast cancer is closely related to the molecular classification of primary foci. Molecular typing can be used as a basis for predicting the prognosis of patients. KeywordsMolecularsubtype, Metastatic breast cancer,Comparison and analysis 背景背景 尽管