208例炎症性肠病临床及病理回顾分析的开题报告

精品文档---下载后可任意编辑 208例炎症性肠病临床及病理回顾分析的开题报告 【摘要】 目的：分析208例炎症性肠病（IBD）患者的临床和病理特征，探讨其诊治进展。 方法：对2024年至2024年期间，我院收治并确诊的208例IBD患者进行回顾性分析。记录其基本情况、病史、症状、体征、实验室检查结果、病理特征、治疗方法及疗效，并探讨它们之间的关系。 结果：208例IBD患者中，76例为溃疡性结肠炎（UC），132例为克罗恩病（CD）。男女比例为1.15：1，平均年龄为36.8岁。UC主要表现为腹泻、便血、腹痛等结肠症状；CD主要表现为腹痛、腹泻等全消化道症状。病理学表现UC主要累及结肠黏膜层，CD则累及全消化道黏膜及肠壁层次。治疗方法主要包括5-氨基水杨酸、免疫抑制剂、生物制剂等。治疗疗效以CD为主，其中采纳生物制剂治疗疗效好于传统药物，而UC治疗效果较传统药物好。 结论：本讨论表明，IBD患者呈年轻化趋势，且男性多于女性。临床表现较为多样，病理学上主要是结肠层面与全消化道受累。生物制剂是治疗CD的首选，而UC适宜采纳传统药物治疗。 【关键词】炎症性肠病；溃疡性结肠炎；克罗恩病；生物制剂；治疗 【Abstract】 Objective: To analyze the clinical and pathological characteristics of 208 patients with inflammatory bowel disease (IBD), and to explore the diagnosis and treatment progress. s: A retrospective analysis was pered on 208 patients with IBD diagnosed and treated at our hospital from 2024 to 2024. The basic ination, medical history, symptoms, signs, laboratory examination results, pathological characteristics, treatment s, and therapeutic effect were recorded, and their relationships were discussed. Results: Among the 208 IBD patients, 76 had ulcerative colitis (UC) and 132 had Crohn s disease (CD). The male-to-female ratio was 1.15:1, and the average age was 36.8 years. UC was mainly manifested as colonic symptoms such as diarrhea, rectal bleeding, and abdominal pain, while CD was mainly manifested as gastrointestinal symptoms such as abdominal pain and diarrhea. The pathological manifestations of UC mainly involved the mucosal layer of the colon, while CD involved the entire gastrointestinal mucosa and intestinal wall layers. The treatment s mainly included 5-aminosalicylic acid, immunosuppressants, and biologics. The treatment effect was mainly on CD, and the use of biologics was better than traditional drugs. The treatment effect of UC was better with traditional drugs. Conclusion: The present study showed that IBD patients tended to be younger, and males were more common than females. The clinical manifestations were diverse, and the pathological manifestations mainly involved the colon and entire gastrointestinal tract. Biologics were the first choice for treating CD, while traditional drugs were more suitable for treating UC. 【Keywords】Inflammatory bowel disease; Ulcerative colitis; Crohn s disease; Biologics; Treatment