医学写作精挑句子

This study used the well-characterized epithelial HeLa cell line as an experimental model system to investigate the first steps of transcription factor binding leading to induction of IL-6 expression by IR. After transient transfection by IR. Thus, to delineate the role of the proximal elements a mutation was introduced into pIL6-1180 which destroyed its ability to interact with AP-1 transcription factors. A multifactorial stress response was found involving three transcription factor recognition elements of the IL-6 promoter, NF-kB, AP-1 and MRE We report here that Fk and IL-1 synergistically enhance IL-6 mRNA expression in FRTL-5 thyroid cells by mechanisms involving the cAMP/PKA pathway, and both stabilization of the IL-6 mRNA and activation of the IL-6 promoter. Point mutations or deletions of the main transcription factor binding sites in the IL-6 promoter indicated that the synergistic effect was mainly mediated by the AP-1 site, and that the CRE site contributed to this effect.These findings contribute to elucidating the synergistic mechanisms that..., , and suggest that... We will then examine the role of NFkB in regulating cytokine production, explore the intricate system of positive and negative feedback loops that control NFkB activation, and uate current ination about the significance of NFkB in the pathobiology of disease quiescent cells Following a stimulus, cytokines are produced in a characteristic pattern that is dependent on the stimulus as well as the cell or tissue type. Of particular importance is that By means of South-Western blotting Flagellin induces IL-6 production in concentration- andtime-dependent fashion Today, various links have been established between chronic inflammation and cancer, converging on the transcription factor NF-q B In this respect, cancer chemopreventive natural compounds, such as Withaferin A, genistein, curcumin, and green tea polyphenols, which interfere with multiple oncogenic pathways converging on the transcription factors NF-q B and AP-1 ,may soon join the arsenal of epigenetic drugs Therefore it is imperative to clarify the regulatory mechanism of the IL-6 gene expression for understanding the deregulation of the IL-6 gene expression and finally the pathogenesis of IL-6-associated disorders. Synthetic oligonucleotides ODN expressing CpG motifs mimic the ability of bacterial DNA to trigger the innate immune system via TLR9. Plasmacytoid dendritic cells pDCs make a critical contribution to the ensuing immune response. up-modulators up-modulation Later Naitoh et al. 7 showed that IL-6 administered i.v. stimulated the increase of ACTH secretion in conscious, freely moving rats. Interleukin-6 IL-6 is a pleiotropic cytokine that is implicated in endocrine and metabolic actions, as well as in immune regulation and aging o Previously we have demonstrated that the IL-6 promoter activity results from a concerted cooperation between NF-kB, AP-1, CREB, and C/EBP transcript