项目名称：肺癌精准诊治策略研究和临床应用

项目名称肺癌精准诊治策略研究和临床应用 项目简介本项目自2007年以来，历时10年，采用二代测序、基因芯片、分子 克隆等先进的方法，对肺癌发生、发展、侵袭转移和耐药的分子机理进行了一系 列的转化医学研究，系统深入地探讨了与肺癌发生、发展、转移、治疗及耐药有 关的分子机理、信号通路及临床应用价值；建立了肺癌个体化诊疗平台，并探讨 胸部肿瘤的发病机制；在开创局部晚期肺癌多种根治手术的基础上，创建局部晚 期肺癌以外科为主的全程管理和综合治疗的特色诊疗模式，提高肺癌患者生存 率。 第一完成单位对本项目的创造性贡献在该项目的实施过程中，总医院在人力、物力、 财力等方面给予大力支持和帮组。总医院内科、外科等多室在多学科会诊、多疾 病综合管理等方面给予了极大支持与配合。科研管理部门在科研立项、课题监管、 经费合理使用、结题验收、成果鉴定及推广应用等方面做了完善的组织工作。 知识产权 1. 陈军，刘红雨，刘明辉，王玉丽，李颖，李永文。发明专利，PD-0332991 在制备防治耐药肿瘤药物的用途，专利授权号CN104758292B。 2. 李梅，陈军，苑记清。实用专利镂空背靠垫。专利授权号CN204972006U 代表性论文专著目录 1. Xuanguang Li, Zhibin Guo, Jinghao Liu, Sen Wei, Dian Ren, Gang Chen, Song Xu*, Jun Chen*,Clinicopathologial characterisitics and molecular analysis of primary pulmonary mucoepidermoid carcinoma Case report and literature review. Thoracic Cancer, 2018 Feb;92316-323. 2. Song Xu, Xia Liu, Renwang Liu, Tao Shi, Xiongfei Li, Diansheng Zhong, Yan Wang*, Gang Chen, Jun Chen*. Concurrent epidermal growth factor receptor T790M secondary mutation and epithelial-mesenchymal transition in a lung adenocarcinoma patient with EGFR TKI drug resistance. Thoracic Cancer, 2017 Nov;86693-697. 3. Xiongfei Li, Renwang Liu, Tao Shi, Shangwen Dong, Fan Ren, Fan Yang, Dian Ren, Haiyang Fan, Sen Wei, Gang Chen Jun Chen*. Song Xu*. Primary pulmonary malignant fibrous histiocytoma case report and literature review. Journal of Thoracic Disease, 2017, 9 8 E702-E708. 4. Renwang Liu, Jinghao Liu, Tao Shi, Xiongfei Li, Dian Ren, Gang Chen,Ying Li, Hongyu Liu, Song Xu,and Jun Chen*,Clinicopathological and genetic characteristics of pulmonary large cell carcinoma under 2015 WHO classification a pilot study.Oncotarget, 2017 Oct 11 ;859 100754-100763. 5. Yongwen Li, Hongbing Zhang, Ying Li, Chenlong Zhao, Yaguang Fan, Jinghao Liu, Xin Li, Hongyu Liu, Jun Chen*. MiR-182 inhibits the epithelial to mesenchymal transition and metastasis of lung cancer cells by targeting the Met gene. Molecular Carcinogenesis. 2018 Jan;57l125-136. 6. Yongwen Li, Hongbing Zhang, Yunlong Dong, Yaguang Fan, Ying Li, Chenlong Zhao, Cong wang,Jinghao Liu Xin Li, Ming Dong, Hongyu Liu, Jun Chen*.MiR- 146b-5p functions as a suppressor miRNA and prognosis predictor in non-small cell lung cancer. Journal of Cancer, 2017,8 ⑼1704-1716 7. Xin Li, Dan Wang, Qingchun Zhao, Dian Ren, Fan Ren, Gang Chen, Hongyu Liu Jun Chen*.Clinical Significance and Next-Generation Sequencing of Chinese Pulmonary Sarcomatoid Carcinoma.Scientific Reports,2017, 7 1 3947 8. Yu Yao, Jinghao Liu, Lei Li, Yuan Yuan, Kejun Nan, Xin Wu, Zhenyu Zhang, Yi Wu, Xin Li, Jiaqi Zhu, Xuehong Meng, Longgang Wei, Jun Chen*, Zhi Jiang*. Detection of circulating tumor DNA in patients with advanced non-small cell lung cancer.Oncotarget, 2017, 82 2130-2140. 9. Minghui Liu, Song Xu, Yuli Wang, Ying Li, Yongwen Li, Hongbing Zhang, Hongyu Liu*, Jun Chen*. PD 0332991, a selective cyclin D kinase 4/6 inhibitor, sensitizes lung cancer cells to treatment with epidermal growth factor receptor tyrosine kinase