[精品]乙型肝炎血清免疫标志物、乙型肝炎病毒核酸水平变化与HBV的关系及临床意义

乙型肝炎血清免疫标志物、乙型肝炎病毒核酸水平变化与HBV的关系 及临床意义 乙型肝炎血清免疫标志物、乙型肝炎病毒核酸水平变化与HBV的关系 及临床意义 ［摘要］目的探讨乙型肝炎血清免疫标志物、乙型肝炎病毒核 酸水平变化与HBV的关系及临床意义。方法选取本院2013年2月〜 2014年2月收治的108例乙型肝炎患者为研究对象，按HBV DNA含 量高低分为A （103拷贝/ml）、B （103〜105拷贝/ml）、C （106〜108 拷贝/ml） 3组，分别检测3组的乙型肝炎血清免疫标志物（HBV M） 与乙型肝炎病毒核酸（HBV DNA）含量。结果A组的HBeAg为 （3. 97114. 47） S/CO, B 组为（446. 7785. 8） S/C0,两组比较， 差异有统计学意义（P〈0.05）； A组的抗-HBe、HBeAg、HBsAg与C组 比较，差异均有统计学意义（P〈0.05）； B组的HBeAg与C组比较， 差异有统计学意义（P〈0.05）； 3组的抗-HBs、抗-HBc比较，差异均 无统计学意义（P0. 05）o HBVM阳性标本中抗-HBs、抗-HBc与HBsAg 含量与HBV DNA无相关性，抗-HBe与HBV DNA呈负相关，HBeAg与 HBV DNA呈正相关。结论 定量检测HBV DNA可真实反映HBV的复制 情况，对于传染性评价、乙型肝炎诊治及疗效观察均具有指导意义; 定量检测HBV M虽在HBV复制程度的判断及传染性评价方面无明显价 值，但可为乙型肝炎数据管理奠定基础。［关键词］乙型肝炎； 血清免疫标志物；乙型肝炎病毒核酸；乙型肝炎病毒 ［中图分类 号］R512. 62 ［文献标识码］A ［文章编号］1674-4721 （2014） 08 （a） -0032-03Relationship between serum immune marker of hepatitis B, level change of hepatitis B virus nucleic acid and clinical significance WANG Xi-jin Department of Gastroenterology, Affiliated Hospital of Jiujiang University, Jiujiang 332000, China ［Abstract］ Objective To explore the relationship between serum immune marker of hepatitis B, level change of hepatitis B virus nucleic acid and clinical significance. s 108 patients with hepatitis B admitted and treated in our hospital from February 2013 to February 2014 were selected as research objects. The patients were assigned to the three groups according to HBV DNA level the group A 103 copy/ml, the group B 103-105 copy /ml and the group C 106-108 copy /ml. The serum immune marker of hepatitis B HBV M and hepatitis B virus nucleic acid HBV DNA content were tested for each group. Results HBeAg in the group A and the group B was 3. 97114. 47 S/CO and 446. 7785. 8 S/CO respectively, and there was a statistical difference in the two groups P0. 05 . The group A and the group C had a statistical difference in anti-HBe, HBeAg and HBsAg level P0. 05 .The group B and the group C had statistical difference in HBeAg level P0. 05 .There was no statistical difference between the three groups in anti-HBs level or anti-HBc level. As for HBV M-positive specimens, anti-HBs level, anti-HBc level and HBsAg level had no correlation with HBV DNA, but anti-HBe level had negative correlation with HBV DNA and HBeAg level had positive correlation with HBV DNA. Conclusion Quantitative detection of HBV DNA level can reflect truly HBV replication, which is of guidence significance for infectivity uation and diagnosis and treatment of hepatitis B and efficacy observation. Although quantitative detection of HBV M has no significant value for HBV replication determination or infectivity uation, but it lays the foundation for management of hepatitis B data. 一endprint一一startprint--[Key words] Hepatitis B； Serum immune marker； Hepatitis B virus nucleic acid； Hepatitis B virus乙型肝炎是临床上常见的传染性疾病之一，其由乙型肝 炎病毒HBV引起，以肝脏炎性病变累及器官并对其造成损害为主 要特征。全球每年因HBV死于晚期肝硬化和肝癌的患者约占因病死亡 患者总数的20,而我国乙型肝炎每年的发病率达7［1］,属于高流 行区［2］,乙型肝炎防治形势十分严峻。定量检测乙型肝炎血清免